Horary is the branch of astrology that deals with answering specific questions. If you do practice horary, there are different methods historically of choosing what planet represents the subject of the question being asked. That planet is called the significator.
If you follow William Lilly, the significator is the ruler of the house which matches the topic of the question- so, for instance, a question about money or possessions would be given to the 2nd house and its lord.
This approach doesn’t necessarily pay much attention to the chart as a whole, and the Ascendant and its lord has no necessary connection to the question.
Another approach would be to look at the natural significator of the topic – so for instance, in a question about a person’s mother you might consider either Venus or the Moon along with the appropriate house.
There is yet another approach that takes the Ascendant and its Lord to indicate the subject of the question regardless of topic. (Ben Dykes points out that this approach is used in Al-Kindi’s influential textbook on horary, Forty Chapters.) Since the chart represents the question then the whole chart, focusing especially on the ascendant, is the focus of the question.
I want to look at an example of a chart from William Lilly’s Christian Astrology, where Lilly read the chart one way, but you could read the chart using other approaches and find the same result. It is a lovely example of multiple markers pointing to the same answer.